在研项目

（1）癌症、心脑血管、呼吸和代谢性疾病防治研究国家科技重大专项课题，2026ZD0556305，基于多组学与AI深度融合的老年肺炎有效方药多靶点协同机制研究，2026/03-2030/02

（2）国家自然科学基金面上项目，82374103，基于肝分泌因子FGL1介导的肝-肾轴探讨丹参-三七药对“泄浊消癥”改善糖尿病肾病的作用机制，2024/01-2027/12

主要论文

1. Xiao-Meng Sun#, Li-Zeng Zhu#, Guo-Dong Wu#, Ting Wang#, Xin-Yue Zhou, Xi-Hua Liu, Qi Wang, Wei Jiang, Bao-Lin Liu, An Pan*, Lian-Wen Qi*, Qun Liu*. A non-enzymatic function of neuraminidase 1 restrains hepatic glucagon response in mice.Nature Communications, 2026,doi: 10.1038/s41467-026-72630-2.

2. Wen-Hui Wu#, Li-Zeng Zhu#, Kang Liu#, Lin Cao, Yuan-Ming Fan, Ping Zhou, Yue Zhang, Gaoxiang Ma, Jin-Feng Liu, Bao-Lin Liu, Lian-Wen Qi*, Qun Liu*. Hepatokine fibrinogen-like protein 1 drives liver-kidney crosstalk to promote renal fibrosis. Nature Communications, 2026, 17, 1453.

3. Xin-Yue Zhou#, Zhongyuan Xu#, Xiwen Liu#, Guiying Wu, Yudong Hou, Lian-Wen Qi*, Qun Liu*, Jianbo Sun*,Bifunctional LYTAC Mediates Hepatocytes-Hepatic Stellate Cells Crosstalk by Regulating 5HT2A Receptor Degradation and Antagonism to Synergistically Ameliorate Hepatic Fibrosis. Journal of the American Chemical Society. 2025,147,44162-44174.

4. An Pan, Xiao-Meng Sun, Feng-Qing Huang, Jin-Feng Liu, Yuan-Yuan Cai, Xin Wu, Raphael N. Alolga, Ping Li, Bao-Lin Liu, Qun Liu*, Lian-Wen Qi*. The mitochondrial β-oxidation enzyme HADHA restrains hepatic glucagon response by promoting β-hydroxybutyrate production. Nature Communications, 2022,19;13(1):386.

5. Wen-Song Zhang, An Pan, Xu Zhang, Ang Ying, Gaoxiang Ma, Bao-Lin Liu, Lian-Wen Qi*, Qun Liu*, Ping Li*, Inactivation of NF-κB2 (p52) restrains hepatic glucagon response via preserving PDE4B induction, Nature Communications, 2019,10(1):4303.

6. Rui Bai#, Li-Zeng Zhu#, Changfa Shao, Zheng Yin, Qun Liu*, Yu Gu*, Bin Liu*，In Situ Assembly of Fluorogenic RNA for Screening Natural Anti-Liver Fibrosis Products via Dynamic Visualization of COL1A1 mRNA. Advanced Science, 2025,e02850.

7. Yue Zhang, Meng-Guang Wei, Xin-Yue Zhou, Lian-Wen Qi*, Qun Liu*. Pharmacological strategies targeting hepatocyte-mediated crosstalk in liver fibrosis. Trends in Pharmacological Sciences, 2026, 47(5):555-570.

在研项目

（1）癌症、心脑血管、呼吸和代谢性疾病防治研究国家科技重大专项课题，2026ZD0556305，基于多组学与AI深度融合的老年肺炎有效方药多靶点协同机制研究，2026/03-2030/02

（2）国家自然科学基金面上项目，82374103，基于肝分泌因子FGL1介导的肝-肾轴探讨丹参-三七药对“泄浊消癥”改善糖尿病肾病的作用机制，2024/01-2027/12

主要论文

1. Xiao-Meng Sun#, Li-Zeng Zhu#, Guo-Dong Wu#, Ting Wang#, Xin-Yue Zhou, Xi-Hua Liu, Qi Wang, Wei Jiang, Bao-Lin Liu, An Pan*, Lian-Wen Qi*, Qun Liu*. A non-enzymatic function of neuraminidase 1 restrains hepatic glucagon response in mice.Nature Communications, 2026,doi: 10.1038/s41467-026-72630-2.

2. Wen-Hui Wu#, Li-Zeng Zhu#, Kang Liu#, Lin Cao, Yuan-Ming Fan, Ping Zhou, Yue Zhang, Gaoxiang Ma, Jin-Feng Liu, Bao-Lin Liu, Lian-Wen Qi*, Qun Liu*. Hepatokine fibrinogen-like protein 1 drives liver-kidney crosstalk to promote renal fibrosis. Nature Communications, 2026, 17, 1453.

3. Xin-Yue Zhou#, Zhongyuan Xu#, Xiwen Liu#, Guiying Wu, Yudong Hou, Lian-Wen Qi*, Qun Liu*, Jianbo Sun*,Bifunctional LYTAC Mediates Hepatocytes-Hepatic Stellate Cells Crosstalk by Regulating 5HT2A Receptor Degradation and Antagonism to Synergistically Ameliorate Hepatic Fibrosis. Journal of the American Chemical Society. 2025,147,44162-44174.

4. An Pan, Xiao-Meng Sun, Feng-Qing Huang, Jin-Feng Liu, Yuan-Yuan Cai, Xin Wu, Raphael N. Alolga, Ping Li, Bao-Lin Liu, Qun Liu*, Lian-Wen Qi*. The mitochondrial β-oxidation enzyme HADHA restrains hepatic glucagon response by promoting β-hydroxybutyrate production. Nature Communications, 2022,19;13(1):386.

5. Wen-Song Zhang, An Pan, Xu Zhang, Ang Ying, Gaoxiang Ma, Bao-Lin Liu, Lian-Wen Qi*, Qun Liu*, Ping Li*, Inactivation of NF-κB2 (p52) restrains hepatic glucagon response via preserving PDE4B induction, Nature Communications, 2019,10(1):4303.

6. Rui Bai#, Li-Zeng Zhu#, Changfa Shao, Zheng Yin, Qun Liu*, Yu Gu*, Bin Liu*，In Situ Assembly of Fluorogenic RNA for Screening Natural Anti-Liver Fibrosis Products via Dynamic Visualization of COL1A1 mRNA. Advanced Science, 2025,e02850.

7. Yue Zhang, Meng-Guang Wei, Xin-Yue Zhou, Lian-Wen Qi*, Qun Liu*. Pharmacological strategies targeting hepatocyte-mediated crosstalk in liver fibrosis. Trends in Pharmacological Sciences, 2026, 47(5):555-570.