李桢，教授，博士生导师。2019年于美国路易斯安那州立大学医学院获药理学博士学位。同年6月，加入该校心血管研究卓越中心从事博士后研究，并获得美国心脏学会（AHA）博士后基金资助。2022年任职于西达赛奈医疗中心，担任项目科学家。2023年入选国家高层次人才计划，并于次年全职加入7MMTV 。
长期致力于心脑血管疾病，特别是心脏疾病的病理生理机制研究及靶标发现工作，同时聚焦气体信号分子在调节代谢稳态中的作用及其对心血管系统生理与病理过程的影响。首次发现线粒体硫化氢合成酶3-MST为支链氨基酸代谢紊乱的关键调控因子，提出通过气体信号分子诱导线粒体代谢重编程以防治慢性心力衰竭的新策略。
多项重要研究成果发表于国际高水平学术期刊，包括JACS（2016）、Angew. Chem. Int. Ed.（2017）、JACC: Basic to Translational Science（2019）、Nature Communications（2023）、Circulation Research（2018，2022，2023，2025）等。兼任 Cardiovascular Drugs and Therapy、Journal of Molecular and Cellular Cardiology、Frontiers in Pharmacology、European Journal of Pharmacology、Journal of Enzyme Inhibition and Medicinal Chemistry 等期刊的同行评审专家。
主持项目：
国家自然科学基金优秀青年科学基金项目
国家自然科学基金青年科学基金项目C类
代表性论文：
1. Li Zet al. Dysregulated Protein s-Nitrosylation Promotes Nitrosative Stress and Disease Progression in Heart Failure with Preserved Ejection Fraction. Circulation Research. Oct 2025.
2. Li Zet al. Alcohol-induced Gut Microbial Reorganization and Associated Overproduction of Phenylacetylglutamine Promotes Cardiovascular Disease. Nature Communications. Dec 2024.
3. Li Zet al. Hydrogen Sulfide Modulates Endothelial-Mesenchymal Transition in Heart Failure. Circulation Research. Jan 2023.
4. Li Zet al. Mitochondrial H2S Regulates BCAA Catabolism in Heart Failure. Circulation Research. Jul 2022.
5. Xia H and Li Zet al. Endothelial Cell Cystathionine γ-Lyase Expression Level Modulates Exercise Capacity, Vascular Function, and Myocardial Ischemia Reperfusion Injury. Journal of American Heart Association. Oct 2020
6. Organ Cand Li Zet al. Nonlethal inhibition of gut microbial trimethylamine N-oxide production improves cardiac function and remodeling in a murine model of heart failure. Journal of American Heart Association. May 2020
7. Li Z,et al. Hydrogen Sulfide Attenuates Renin Angiotensin and Aldosterone Pathological Signaling and Improves Exercise Tolerance in Heart Failure. JACC: Basic to Translational Science. Dec 2018
8. Li Zet al. Evolution of Hydrogen Sulfide Therapeutics to Treat Cardiovascular Disease. Circulation Research. Aug 2018.
9. ZhengY, YuB, and Li Zet al. A Novel Esterase-sensitive Prodrug Approach for Controllable Delivery of Persulfide Species. Angewandte Chemie. 2017
10.Kang J and Li Z et al. pH-Controlled Hydrogen Sulfide Release for Myocardial Ischemia-Reperfusion Injury. Journal of the American Chemical Society. May 2016.
热忱欢迎有志于开展学科交叉研究的同学报考（如病理生理学、流行病学、细胞/分子生物学、生物信息学等）！
