吴斐华

师资队伍

当前位置：7MMTV 师资队伍中药药理与中医药学系教授/（特聘）研究员

吴斐华

教授博士生导师

电话：邮箱：[email protected]

办公室地址：

研究领域：中药抗代谢性疾病药理学研究、中药抗糖尿病血管并发症研究

招生方向：中药学-中药药理与临床中药学；中药-中药药效与安全性评价

主持的主要科研项目：
1. 国家自然科学基金面上项目、81873061、基于AMPK-TFEB通路研究高车前苷调控自噬改善糖尿病血管病变的作用机制、2019-2022、57万元、主持
2. 国家自然科学基金青年科学基金项目、81102862、风轮菜改善糖尿病血管内皮功能障碍的作用机制与物质基础研究、2012-2014、20万元、主持
3. 江苏省自然科学基金面上项目、BK2012758、高车前苷调节TLR4/NF-kB通路改善糖尿病血管内皮功能障碍的研究、2012-2015、10万元、主持
4. 安徽农业大学国家重点实验室开放基金项目、SKLTOF20170103、黄茶调节自噬改善糖尿病血管内皮损伤的作用机制研究、2017-2019、8万元、主持

近年发表的论文
1. Li XL^#, Wang JW^#, Wang L, Sha XT, Huang SC, Ren MS, Cheng L, Zhang YF, Zhou WL, Lin YN*, Wu FH*. Homoplantaginin alleviates high glucose-induced vascular endothelial barrier dysfunction by regulating Yes-associated protein 1. Phytomedicine, 2026, 153:157953.
2. Zheng JM^#, Cheng L^#, Wei YM, Ren MS, Wang L, Wang JW, Zhou WL, Huang H*, Wu FH*. Scutellarin alleviates hepatic steatosis by autophagy-mediated NCoR1/PPARα-driven fatty acid β-oxidation and enhancing peroxisome biogenesis. Phytother Res., 2026, May 5. Epub ahead of print.
3. Wang L^#, Zhang XY^#, Huang X, Sha XT, Li XL, Zheng JM, Li ST, Wei ZF*, Wu FH*. Homoplantaginin alleviates high glucose-induced vascular endothelial senescence by inhibiting mtDNA–cGAS–STING pathway via blunting DRP1–mitochondrial fission–VDAC1 axis. FASEB J., 2024, 38: e70127.
4. Ren MS^#, Ren JY^#, Zheng JM, Sha XT, Lin YN*, Wu FH*.Clinopodium gracile alleviates metabolic dysfunction-associated steatotic liver disease by upregulating peroxisome proliferator-activated receptor α and inhibiting mitochondrial oxidative damage. Antioxidants, 2024,13: 1136
5. Fan LL^#, Zhang XY^#, Huang YH, Zhang BB, Li WJ, Shi QR, Lin YN*, Wu FH*. Homoplantaginin attenuates high glucose-induced vascular endothelial cell apoptosis through promoting autophagy via the AMPK/TFEB pathway, Phytother Res., 2023, 37(7): 3025-3041.
6. Zhou YY^#, Wang L^#, Liu YC, Fan LL, Zhang XY, Shi QR, Li XL, Lin YN*, Wu FH*. Homoplantaginin attenuates high glucose-induced vascular endothelial dysfunction via inhibiting store-operated calcium entry channel and endoplasmic reticulum stress. J Pharm Pharmacol., 2023, 75(12): 1530-1543.
7. Zhang XY, Huo ZJ, Luan HL, Huang YH, Shen YH, Sheng L, Liang JY, Wu FH*. Scutellarin ameliorates hepatic lipid accumulation by enhancing autophagy and suppressing IRE1 alpha/XBP1 pathway. Phytother Res., 2022, 36: 433–447.
8. Wang P^#, Huang YH^#, Ren JY, Rong YZ, Fan LL, Zhang P, Xueying Zhang, Junxiao Xi, Shuying Mao, Min Su, Zhang BB, Bao GH*, Wu FH*. Large-leaf yellow tea attenuates high glucose-induced vascular endothelial cell injury by up-regulating autophagy and down-regulating oxidative stress., Food Funct., 2022, 13（4）: 1890–1905
9. Xi JX^#, Rong YZ^#, Zhao ZF, Huang YH, Wang P, Luan HL, Xing Y, Li SY, Liao J*, Yue Dai, Liang JY, Wu FH*. Scutellarin ameliorates high glucose-induced vascular endothelial cells injury by activating PINK1/Parkin-mediated mitophagy. J Ethnopharmacol., 2021, 271: 113855.
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主讲《中药药理学》、《药理学》、《人体解剖生理学》等课程，教学效果优良。
中药抗代谢性疾病药理学研究、中药抗糖尿病血管并发症研究。
主持的主要科研项目：
1. 国家自然科学基金面上项目、81873061、基于AMPK-TFEB通路研究高车前苷调控自噬改善糖尿病血管病变的作用机制、2019-2022、57万元、主持
2. 国家自然科学基金青年科学基金项目、81102862、风轮菜改善糖尿病血管内皮功能障碍的作用机制与物质基础研究、2012-2014、20万元、主持
3. 江苏省自然科学基金面上项目、BK2012758、高车前苷调节TLR4/NF-kB通路改善糖尿病血管内皮功能障碍的研究、2012-2015、10万元、主持
4. 安徽农业大学国家重点实验室开放基金项目、SKLTOF20170103、黄茶调节自噬改善糖尿病血管内皮损伤的作用机制研究、2017-2019、8万元、主持

近年发表的论文
1. Li XL^#, Wang JW^#, Wang L, Sha XT, Huang SC, Ren MS, Cheng L, Zhang YF, Zhou WL, Lin YN*, Wu FH*. Homoplantaginin alleviates high glucose-induced vascular endothelial barrier dysfunction by regulating Yes-associated protein 1. Phytomedicine, 2026, 153:157953.
2. Zheng JM^#, Cheng L^#, Wei YM, Ren MS, Wang L, Wang JW, Zhou WL, Huang H*, Wu FH*. Scutellarin alleviates hepatic steatosis by autophagy-mediated NCoR1/PPARα-driven fatty acid β-oxidation and enhancing peroxisome biogenesis. Phytother Res., 2026, May 5. Epub ahead of print.
3. Wang L^#, Zhang XY^#, Huang X, Sha XT, Li XL, Zheng JM, Li ST, Wei ZF*, Wu FH*. Homoplantaginin alleviates high glucose-induced vascular endothelial senescence by inhibiting mtDNA–cGAS–STING pathway via blunting DRP1–mitochondrial fission–VDAC1 axis. FASEB J., 2024, 38: e70127.
4. Ren MS^#, Ren JY^#, Zheng JM, Sha XT, Lin YN*, Wu FH*.Clinopodium gracile alleviates metabolic dysfunction-associated steatotic liver disease by upregulating peroxisome proliferator-activated receptor α and inhibiting mitochondrial oxidative damage. Antioxidants, 2024,13: 1136
5. Fan LL^#, Zhang XY^#, Huang YH, Zhang BB, Li WJ, Shi QR, Lin YN*, Wu FH*. Homoplantaginin attenuates high glucose-induced vascular endothelial cell apoptosis through promoting autophagy via the AMPK/TFEB pathway, Phytother Res., 2023, 37(7): 3025-3041.
6. Zhou YY^#, Wang L^#, Liu YC, Fan LL, Zhang XY, Shi QR, Li XL, Lin YN*, Wu FH*. Homoplantaginin attenuates high glucose-induced vascular endothelial dysfunction via inhibiting store-operated calcium entry channel and endoplasmic reticulum stress. J Pharm Pharmacol., 2023, 75(12): 1530-1543.
7. Zhang XY, Huo ZJ, Luan HL, Huang YH, Shen YH, Sheng L, Liang JY, Wu FH*. Scutellarin ameliorates hepatic lipid accumulation by enhancing autophagy and suppressing IRE1 alpha/XBP1 pathway. Phytother Res., 2022, 36: 433–447.
8. Wang P^#, Huang YH^#, Ren JY, Rong YZ, Fan LL, Zhang P, Xueying Zhang, Junxiao Xi, Shuying Mao, Min Su, Zhang BB, Bao GH*, Wu FH*. Large-leaf yellow tea attenuates high glucose-induced vascular endothelial cell injury by up-regulating autophagy and down-regulating oxidative stress., Food Funct., 2022, 13（4）: 1890–1905
9. Xi JX^#, Rong YZ^#, Zhao ZF, Huang YH, Wang P, Luan HL, Xing Y, Li SY, Liao J*, Yue Dai, Liang JY, Wu FH*. Scutellarin ameliorates high glucose-induced vascular endothelial cells injury by activating PINK1/Parkin-mediated mitophagy. J Ethnopharmacol., 2021, 271: 113855.